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Design and Analysis of Clinical Trials

Design and Analysis of Clinical Trials
Praise for the First Edition of Design clinic springfield missouri and Analysis of Clinical Trials An excellent book, providing a discussion of the clinical trial process from designing the study through analyzing the data, clinic springfield missouri and to regulatory requirement . . . could easily be used as a classroom text to understand the process in the new drug development area. -Statistical Methods in Medicine A complete clinic springfield missouri and balanced presentation now revised, updated, clinic springfield missouri and expanded As the field of research possibilities expands, the need for a working understanding of how to carry out clinical trials only increases. New developments in the theory clinic springfield missouri and practice of clinical research include a growing body of literature on the subject, new technologies clinic springfield missouri and methodologies, clinic springfield missouri and new guidelines from the International Conference on Harmonization (ICH). Design clinic springfield missouri and Analysis of Clinical Trials, Second Edition provides both a comprehensive, unified presentation of principles clinic springfield missouri and methodologies for various clinical trials, clinic springfield missouri and a well-balanced summary of current regulatory requirements. This unique resource bridges the gap between clinical clinic springfield missouri and statistical disciplines, covering both fields in a lucid clinic springfield missouri and accessible manner. Thoroughly updated from its first edition, the Second Edition of Design clinic springfield missouri and Analysis of Clinical Trials features new topics such as: * Clinical trials clinic springfield missouri and regulations, especially those of the ICH * Clinical significance, reproducibility, clinic springfield missouri and generalizability * Goals of clinical trials clinic springfield missouri and target population * New study designs clinic springfield missouri and trial types * Sample size determination on equivalence clinic springfield missouri and noninferiority trials, as well as comparing variabilities Also, three entirely new chapters cover: * Designs for cancer clinical trials * Preparation clinic springfield missouri and implementation of a clinical protocol * Data management of a clinical trial Written with the practitioner in mind, the presentation assumes only a minimal mathematical clinic springfield missouri and statistical background for its Copyright (C) Muze Inc. 2005. For personal use only. All r
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Clinical Trials

Clinical Trials
Clinical Trials A Practical Approach Stuart J. Pocock Professor of Medical Statistics clinic springfield missouri and Director of Clinical Trials Research Group London School of Hygiene clinic springfield missouri and Tropical Medicine, University of London, UK It is well recognized that randomized clinical trials play an important role in the evaluation of new treatments. However, the reliable achievement of genuine patient benefit depends on clinical trials being well organized clinic springfield missouri and conducted according to proper ethical clinic springfield missouri and scientific standards. This comprehensive text on the principles clinic springfield missouri and practice of clinical trials gives a detailed account of how to conduct trials clinic springfield missouri and also provides a general perspective on their historical development, current status clinic springfield missouri and future strategy. Each aspect of clinical trial design, analysis clinic springfield missouri and interpretation is described in a non-technical manner clinic springfield missouri and illustrated by actual trials. In particular, relevant statistical methods are clearly explained for clinicians clinic springfield missouri and others without statistical training. This book will be essential reading for clinicians, statisticians, medical students, the pharmaceutical industry clinic springfield missouri and anyone wishing to acquire a true understanding of clinical trials.‘The purpose of this book is to explain in practical terms the basic principles of clinical trials.… This book succeeds admirably in this aim clinic springfield missouri and is accessible to a wide audience, including clinical investigators, statisticians, clinic springfield missouri and those involved in data management clinic springfield missouri and the administration of clinical trials.’ Controlled Clinical Trials‘This book is an outstanding practical guide to the design, planning, execution clinic springfield missouri and analysis of clinical trials.’ Journal of the Royal Society of Medicine‘Pocock’s book is a helpful clinic springfield missouri and thoughtful one… of considerable value to clinicians who are drawn into clinical trials.’ The Lancet‘This is an excellent book… which will be of value to anyone beginning work in the field of clinical trials, but at the same time it provid... Copyr
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